Matt Bomer as Clark Kent / Superman (voice)

John Noble as Brainiac (voice)

Stana Katic as Lois Lane (voice)

Molly C. Quinn as Kara Zor-El / Supergirl (voice)

Diedrich Bader as Steve Lombard (voice)

Jason Beghe as Terrorist Leader (voice)

Frances Conroy as Ma Kent (voice)

Melissa Disney as Thara (voice)

Alexander Gould as Jimmy Olsen (voice)

Sirena Irwin as Alura (voice)

Will Yun Lee as Parasoldier Leader (voice)

Andrea Romano as News Anchor #2 / Superman's Ship (voice)

Stephen Root as Zor-El (voice)

Wade Williams as Perry White (voice)

Michael-Leon Wooley as Ron Troupe (voice)

Ian James Corlett as Kryptonian #1 (voice)