Jamie Foxx as Ray Charles

Kerry Washington as Della Bea Robinson

Regina King as Margie Hendricks

Harry Lennix as Joe Adams

Clifton Powell as Jeff Brown

Bokeem Woodbine as Fathead Newman

Sharon Warren as Aretha Robinson

C.J. Sanders as Young Ray Robinson

Curtis Armstrong as Ahmet Ertegun

Richard Schiff as Jerry Wexler

Larenz Tate as Quincy Jones

Terrence Howard as Gossie McGee

David Krumholtz as Milt Shaw

Wendell Pierce as Wilbur Brassfield

Aunjanue Ellis-Taylor as Mary Ann Fisher

Chris Thomas King as Lowell Fulson

Thomas Jefferson Byrd as Jimmy

Rick Gomez as Tom Dowd

Denise Dowse as Marlene

Warwick Davis as Oberon

Patrick Bauchau as Dr. Hacker

Robert Wisdom as Jack Lauderdale

Kurt Fuller as Sam Clark

Jedda Jones as Mercedes

Gary Grubbs as Billy Ray

Carol Sutton as Eula

Paula Jai Parker as Ruth Brown

Eric O'Neal Jr. as Ray Charles Jr. - 5-6 Yrs.

Tequan Richmond as Ray Charles Jr. - 9-10 Yrs.

Ayanna Tatum as Woman in Sandpiper Lounge (uncredited)

Afemo Omilami as Angry Husband