Michael Keaton as John Kelly (aka Johnny Dangerously)

Peter Boyle as Jocko Dundee

Griffin Dunne as Tommy Kelly

Marilu Henner as Lil

Joe Piscopo as Danny Vermin

Maureen Stapleton as Ma Kelly

Dom DeLuise as The Pope

Danny DeVito as Burr

Glynnis O'Connor as Sally

Vincent Schiavelli as

Ray Walston as Gabe, the Newsstand Vendor

Sudie Bond as Mary Margaret Catherine Dineen

Ron Carey as Pat

Richard Dimitri as Roman Troy Moroni

Bob Eubanks as Radio Announcer at Movie Premiere

Jack Nance as Priest

Mike Bacarella as Vito

Byron Thames as Young Johnny

Chuck Hicks as Governor

Hank Garrett as Mayor

Alan Hale Jr. as Desk Sergeant

Taylor Negron as Delivery Man

Joe Flaherty as Deathrow Inmate

Elizabeth Arlen as Girl on Steps

Scott Thomson as Charley

Dick Butkus as Arthur