Dwayne Johnson as Capt. Charles 'Chuck' Baker (voice)

Seann William Scott as Skiff (voice)

Jessica Biel as Neera (voice)

Justin Long as Lem / Rover (voice)

Gary Oldman as General Grawl (voice)

John Cleese as Professor Kipple (voice)

Alan Marriott as Glar (voice)

Freddie Benedict as Eckle (voice)

Mathew Horne as Soldier Vesklin (voice)

James Corden as Soldier Vernkot (voice)

Lewis Macleod as Additional Voices (voice)

Rupert Degas as Additional Voices / Chief Gorlock (voice)

Rebecca Front as Additional Voices (voice)

Vincent Marzello as Additional Voices (voice)

Emma Tate as Additional Voices (voice)

Pete Atkin as Additional Voices (voice)

Laurence Bouvard as Additional Voices (voice)

Brian Bowles as Additional Voices (voice)