Tim Daly as Clark Kent / Superman (voice)

Kevin Conroy as Bruce Wayne / Batman (voice)

Dana Delany as Lois Lane (voice)

Clancy Brown as Lex Luthor (voice)

Mark Hamill as The Joker (voice)

Arleen Sorkin as Harley Quinn (voice)

Lisa Edelstein as Mercy Graves (voice)

Bob Hastings as Commissioner Jim Gordon (voice)

Efrem Zimbalist Jr. as Alfred Pennyworth (voice)

Joseph Bologna as SCU Lt. Dan Turpin (voice)

Robert Costanzo as Detective Harvey Bullock (voice)

George Dzundza as Perry White (voice)

Lauren Tom as Angela Chen (voice)

Brad Garrett as Bibbo (voice)