James McAvoy as Conor

Jessica Chastain as Eleanor Rigby

Bill Hader as Stuart

Ciarán Hinds as Spencer Ludlow

Nina Arianda as Alexis

Isabelle Huppert as Mary Rigby

Viola Davis as Professor Lillian Friedman

Jeremy Shamos as Evangelist

Nikki M. James as Sia

Marta Milans as Phoebe

Isabelle McNally as Dine & Ditch Girl

Justine Salata as Bar Fight Girl

Susanna Guzman as Hospital Receptionist

Nicole Neuman as Kara

Christian Coulson as Dine & Ditch Guy

Musto Pelinkovicci as Ukrainian Cabbie

Johnathan Fernandez as Bar Fight Guy

Jimmy Palumbo as Rental Car Attendant

Rafael Feldman as Paramedic