Joaquin Phoenix as Larry "Doc" Sportello

Josh Brolin as Lt. Det. Christian F. "Bigfoot" Bjornsen

Owen Wilson as Coy Harlingen

Katherine Waterston as Shasta Fay Hepworth

Reese Witherspoon as Deputy D.A. Penny Kimball

Benicio del Toro as Sauncho Smilax, Esq.

Jena Malone as Hope Harlingen

Joanna Newsom as Sortilège, who is also the narrator

Jordan Christian Hearn as Denis

Hong Chau as Jade

Jeannie Berlin as Aunt Reet

Maya Rudolph as Petunia Leeway

Michael Kenneth Williams as Tariq Khalil

Martin Short as Dr. Rudy Blatnoyd, D.D.S.

Sasha Pieterse as Japonica Fenway

Martin Donovan as Crocker Fenway

Eric Roberts as Michael Z. "Mickey" Wolfmann

Serena Scott Thomas as Sloane Wolfmann

Christopher Allen Nelson as Glenn Charlock

Sam Jaeger as Agent Flatweed

Timothy Simons as Agent Borderline

Jillian Bell as Chlorinda

Taylor Bonin as Ensenada Slim

Martin Dew as Dr. Buddy Tubeside

Shannon Collis as Bambi

Catherine Haena Kim as News Reporter

Vivienne Khaledi as Amethyst Harlingen

Yvette Yates Redick as Luz

Andrew Simpson as Riggs Warbling

Joe Dioletto as Cop with Bigfoot

Jack Kelly as Burke Stodger (archive footage)

The Growlers as The Boards

Belladonna as Clancy Charlock

Alina Gatti as Howdy Doper's Phone Voice (voice)

Elaine Tan as Xandra

Wilson Bethel as LAPD Officer #1

Anders Holm as LAPD Officer #2

Emmet Unverzagt as Bigfoot's Kid

Erica Sullivan as Dr. Lily Hammer

Eva Fisher as Dr. Threeply's Assistant #1

Jackie Michele Johnson as Dr. Threeply's Assistant #2

Katie Schwartz as Kimberly

Charley Morgan as Dr. Igor

Keith Jardine as Puck Beaverton

Delaina Mitchell as Mrs. Chastity Bjornsen

Michael Cotter as Rhus Frothingham

Peter McRobbie as Adrian Prussia

Shannon C. Sullivan as Adrian Prussia's Secretary

Samantha Lemole as Golden Fang Mother

Madison Leisle as Golden Fang Daughter

Liam Van Joosten as Golden Fang Son

Matt Doyle as Golden Fang Father

Christian Williams as Smedley

Jefferson Mays as Dr. Threeply

David Prak as Buddhist Monk

Amy Ferguson as Bodhi

Emma Dumont as Zinnia

Scott Aschenbrenner as Jesus Guard (uncredited)

Christina Bobrowsky as Patient (uncredited)

Peter Bonilla as Police Officer (uncredited)

Gregoer Boru as Recording Tech (uncredited)

Marianne Bourg as Beach Girl (uncredited)

Toyia Brown as Harmony (uncredited)

Stu Brumbaugh as Groupie (uncredited)

Seth Cash as Detective (uncredited)

Laura Lyon Rossi as Groupie (uncredited)

Ashleigh Biller as Patient (uncredited)

Elizabeth Colunga as Patient (uncredited)

Emma Cooper as Groupie (uncredited)

Nick de Graffenreid as Patient (uncredited)

Adam Dorsey as Jesus Guard (uncredited)

Ken Edling as Judge (uncredited)

Jenna Emery as Groupie (uncredited)

Al Function as Biker (uncredited)

Brandy Futch as Flight Attendant (uncredited)

Lauren Goncher as Dental Assistant (uncredited)

Ellen Ho as Chinese Waitress (uncredited)

Jessica Huss as Speed Freak (uncredited)

Robert Peoples as Patient (uncredited)

Dallas James as Auto Mechanic (uncredited)

Christopher Karl Johnson as Mr. Robinson (uncredited)

Timothy Lally as Commando (uncredited)

Adeana Lane as Beach Girl (uncredited)

Kira Legg as Groupie (uncredited)

Tracy Ann Lisa as District Attorney (uncredited)

Blue LoLan as Patient (uncredited)

Jacob Lyman as Mormon FBI Agent (uncredited)

Amanda Maddox as Flight Attendant (uncredited)

Emilee Madrak as Groupie (uncredited)

Kirstin Masters as Dental Assistant (uncredited)

Zach McMahon as Police Officer (uncredited)

Chelsea O'Toole as Patient (uncredited)

Shaun Parker as Commando (uncredited)

Rodney J. Richards as Adrian Prussia's Friend (uncredited)

Philip Roosevelt as Hippie in Commune (uncredited)

Osamu Saito as Japanese Waiter (uncredited)

Joel Shock as Police Officer (uncredited)

Matthew Skomo as Detective (uncredited)

Chantal Thuy as Groupie (uncredited)

Diana Elizabeth Torres as Lourdes (uncredited)