David Duchovny as Mike Klein

Sigourney Weaver as Lenny

Ioan Gruffudd as Richard McCallister

Judy Greer as Alice

Fran Kranz as Zach Harper

Lindsay Sloane as Laurel Simon

Justine Bateman as Natalie Klein

Lucy Davis as Chloe McCallister

Willie Garson as Brian

M.C. Gainey as Hutch

Philip Baker Hall as Vernon Maxwell

Wendle Josepher as A.D.

Phil Rosenthal as Exec. #1 (Cooper)

David Doty as Exec. #2 (Rose)

Matt Price as Exec. #3 (Berg)

Simon Helberg as TJ Goldman

Kaitlin Doubleday as Jesse Filmore

Marcia Moran as Casting Director

Andrea Martin as Becky

Charlotte Salt as Sarah

Vernee Watson-Johnson as Barbara

Maurice G. Smith as Guard

Molly Bryant as Peggy Wallace

Aidan Mitchell as Simon McCallister

Alan Blumenfeld as Dr. Schwartz

Kathryn Joosten as Lois

Stuart Cornfeld as Mixer

Dakota Sky as Jared

Martin Morales as Carlos (Newspaper Guy)

Allison Scagliotti as Bethany

Brad Campbell as Coach

Jordan Orr as Robby

Matt Besser as Market Research Guy

Ray Santiago as Audience Member #1

Lillian Adams as Audience Member #2

Ilyse Mimoun as Market Researcher

Don Hany as Guy (in Mall)

Bree Turner as Carla

Amanda Anka as Publicist

Nat Faxon as Reporter

Jonathan Silverman as Self

Bryan Law as Photographer

R.F. Daley as Guy

Rob Reinis as "Chuck Wexler"

Tony Rodgers as Upfront Announcer (voice)

Seth Green as Slut Wars Host (uncredited)