Owen Wilson as Reggie (voice)

Woody Harrelson as Jake (voice)

Amy Poehler as Jenny (voice)

George Takei as S.T.E.V.E. (voice)

Colm Meaney as Myles Standish (voice)

Keith David as Chief Broadbeak (Voice)

Dan Fogler as Governor William Bradford (voice)

Jimmy Hayward as Ranger / Leatherbeak / President / Hazmats (voice)

Jeff Biancalana as General Sagan / Hazmats (voice)

Danny Carey as Danny (voice)

Carlos Ponce as Narrator / Alejandro (voice)

Robert Beltran as Chief Massasoit (voice)

Lesley Nicol as Female Pilgrim (voice)

Kaitlyn Maher as President's Daughter (voice)

Carlos Alazraqui as Amos (voice)

Josh Lawson as Gus (Voice)

Jason Finazzo as Chrononaut One (voice)

Scott Mosier as Pizza Dude (voice)

Lauren Bowles as Jake's Mother (voice)

Dwight Howard as Cold Turkey (Voice)

Vincente DiSanti as (voice)

Jeff Fierson as (voice)

David S. Lee as (voice)

Rik Michul as (voice)

Alina Phelan as (voice)

William Morgan Sheppard as (voice)