Jack Black as Zed

Michael Cera as Oh

Oliver Platt as High Priest

David Cross as Cain

Christopher Mintz-Plasse as Isaac

Vinnie Jones as Sargon

Hank Azaria as Abraham

Juno Temple as Eema

Olivia Wilde as Princess Inanna

June Diane Raphael as Maya

Xander Berkeley as King

Gia Carides as Queen

Horatio Sanz as Enmebaragesi

David Pasquesi as Prime Minister

Matthew Willig as Marlak

Harold Ramis as Adam

Rhoda Griffis as Eve

Gabriel Sunday as Seth

Eden Riegel as Lilith

Kyle Gass as Zaftig the Eunuch

Bill Hader as Shaman

Marshall Manesh as Slave Trader

Rion Hunter as Bedouin Sheik

Gene Stupnitsky as First Guard

Lee Eisenberg as Sodom Sentry

Eric Gipson as Sodom Vendor

Lacie Manshack as Banana Girl

Matt Besser as Guy in Crowd

Drue Franklin as Squanto

Weston Hollenshead as Kid Stoner

Paul Scheer as Bricklayer

Joaquin Townsend as Slave Child

Bryan Massey as New Guard

Keet Davis as Desert Soldier

Tim Hilton as Pedestrian Villager

Ashley Nicole Caldwell as Gold Statue

Mark Cotone as Angry Baker

Jack Walker as Village Child

Jamal Sims as Dancer

Paul Benshoof as Dancer

Kelly Connolly as Dancer

Leslie Geldbach as Dancer

Katherine Miller as Dancer

Michael Morris as Dancer

Sarah Christine Smith as Dancer

Paul Rudd as Abel (uncredited)

Laura McDavid as Gatherer (uncredited)