John Wayne as Dan Roman

Claire Trevor as May Holst

Laraine Day as Lydia Rice

Robert Stack as John Sullivan

Jan Sterling as Sally McKee

Phil Harris as Ed Joseph

Robert Newton as Gustave Pardee

David Brian as Ken Childs

Paul Kelly as Donald Flaherty

Sidney Blackmer as Humphrey Agnew

Julie Bishop as Lillian Pardee

Pedro Gonzalez Gonzalez as Gonzales

John Howard as Howard Rice

Wally Brown as Lenny Wilby, navigator

William Campbell as Hobie Wheeler

Ann Doran as Clara Joseph

John Qualen as Jose Locota

Paul Fix as Frank Briscoe

George Chandler as Ben Sneed

Joy Kim as Dorothy Chen

Michael Wellman as Toby Fields

Douglas Fowley as Alsop

Regis Toomey as Tim Garfield

Robert Keys as Lieutenant Mowbray

William Hopper as Roy

William Schallert as Dispatcher

Julie Mitchum as Susie Wilby

Doe Avedon as Miss Spalding

Karen Sharpe as Nell Buck

John Smith as Milo Buck

Robert Easton as Cargo Clerk (uncredited)

Douglas Kennedy as Boyd, Public Relations (uncredited)

Walter Reed as Mr. Field (uncredited)

Carl Switzer as Ensign Keim

William H. O'Brien as Restaurant Cook