Tom Holland as Peter Parker / Spider-Man

Jake Gyllenhaal as Quentin Beck / Mysterio

Samuel L. Jackson as Nick Fury

Marisa Tomei as May Parker

Jon Favreau as Happy Hogan

Zendaya as MJ

Jacob Batalon as Ned Leeds

Tony Revolori as Flash Thompson

Angourie Rice as Betty Brant

Remy Hii as Brad Davis

Martin Starr as Mr. Harrington

JB Smoove as Mr. Dell

Jorge Lendeborg Jr. as Jason Ionello

Cobie Smulders as Maria Hill

Numan Acar as Dimitri

Zach Barack as Zach

Zoha Rahman as Zoha

Yasmin Mwanza as Yasmin

Joshua Sinclair-Evans as Josh

Tyler Luke Cunningham as Tyler

Sebastián Viveros as Sebastian

Toni Garrn as The Seamstress

Peter Billingsley as William Ginter Riva

Clare Dunne as Victoria

Nicholas Gleaves as Guterman

Claire Rushbrook as Janice

J.K. Simmons as J. Jonah Jameson

Dawn Michelle King as E.D.I.T.H. (voice)

Jeroen van Koningsbrugge as Dutch Soccer Hooligan

Michael de Roos as Dutch Soccer Hooligan

Jan-Paul Buijs as Dutch Soccer Hooligan

Sergio Pierattini as Venetian Glassblower

Anjana Vasan as Queens Reporter

Brian Law as Queens Reporter

Evelyn Mok as Queens Reporter

Tatiana Lunardon as Italian TV Newsreader

Giada Benedetti as Italian Customs Office

Lukáš Bech as Helpful Dutch Man

Alessandro Giuggioli as Italian Street Vendor

Petr Opava as Opera Singer

Giuseppe Andriolo as Caricaturist

Pat Kiernan as Pat Kiernan

Shari Abdul as High School Reporter (uncredited)

Mari Alexandrova as Tourist in Venice (uncredited)

Kristen Alminta as Police Officer (uncredited)

Vincent Angel as Midtown High Student (uncredited)

Peter Arpesella as Airplane Pilot (uncredited)

Lasco Atkins as Salvation Army guest (uncredited)

Sitara Attaie as Dutch Lady (uncredited)

Peter Bankolé as Mob Boss (uncredited)

Blair Barnette as Queens Reporter (uncredited)

Tuwaine Barrett as Officer Bristow (extended cut)

Anna Benamati as Shop Owner in Venice (uncredited)

Avondre E.D. Beverley as High School Student (uncredited)

Bruno Bilotta as Mob Boss (uncredited)

Sharon Blynn as Soren (uncredited)

Luigi Boccanfuso as Italian Builder in Venice (uncredited)

Paolo Braghetto as Poliziotto (uncredited)

Dante Brattelli as High School Student (uncredited)

Graham Burton as London Passerby (uncredited)

Ken Byrd as Post Office Customer (uncredited)

Sokol Cahani as Mob Boss (uncredited)

Darren Lee Campbell as Victoria's Crew (uncredited)

Hélène Cardona as Austrian Backpacker (uncredited)

Dian Cathal as American Reporter (uncredited)

Jake Cerny as Airport Traveler (uncredited)

Daphne Cheung as Passport Clerk (uncredited)

Sam Chuck as High School Student (uncredited)

Victoria Coburn as Passerby (uncredited)

Kimberly Collison as Charity Event Mom (uncredited)

Tiziana Coste as Local Venetian (uncredited)

Jaylen Davis as Tourist (uncredited)

Kristianne-Kaith Domingo as Passerby (uncredited)

Andrew Dunkelberger as Courier (uncredited)

Charlie Esquér as Mexican Survivor (uncredited)

Ria Fend as Tourist in Venice (uncredited)

Ferroz Fernandez as Tourist in Venice (uncredited)

Vincent Frattini as Venice Local (uncredited)

Massi Furlan as Flight Attendant (uncredited)

Cynthia Garbutt as Charity Dinner Guest (uncredited)

Thomas Goodridge as Tourist in Venice (uncredited)

Sonia Goswami as Tourist (uncredited)

Nicholle Hembra as Saved Londoner (uncredited)

Michael Hennessy as Hotel Guest (uncredited)

Meagan Holder as Pretty Tourist (uncredited)

Patrick Doran as Partygoer (uncredited)

Ruth Clarson as Tourist (uncredited)

Chris Hyacinthe as Sneezy Tour Guide (uncredited)

Michael Iacono as Airport Kid Traveler (uncredited)

Roman Ibragimov as Bar Customer (uncredited)

Theo Ip as Tourist (uncredited)

Timothy Christian Jansen as High School Student (uncredited)

Keon Kendrick as Flight Attendant (uncredited)

Camille Kinloch as Midtown High School Student (uncredited)

Michal Kubal as Czech TV News Anchor (uncredited)

Hannah Kurczeski as Student (uncredited)

Géraldine Lamarre as Traffic Warden (uncredited)

Jimena Larraguivel as Mexican Villager (uncredited)

Rich Lawton as Journalist (uncredited)

Kat Leroy as Czech Traditional Dancer (uncredited)

Gavin Lee Lewis as Londoner (uncredited)

Patrick Loh as Airport Passenger (uncredited)

Joseph Long as Mob Boss (uncredited)

Marian Lorencik as New Czech Reveler (uncredited)

Ketan Majmudar as Berlin Commuter (uncredited)

Tony Mardon as Londoner (uncredited)

Antonín Mašek as Bellboy (uncredited)

Ben Mendelsohn as Talos (uncredited)

Bradley Wj Miller as Passerby (uncredited)

Melissa Beth Miller as Tourist (uncredited)

Anthony Molinari as Mob Guy (uncredited)

Adrian Mozzi as Venice Local (uncredited)

Brendan Murphy as Police Officer (uncredited)

Amanda Musso as Carnival Hot Girl (uncredited)

Emily Ng as Italian Tourist (uncredited)

Daniel Olson as Czech Guy (uncredited)

Hiten Patel as British Station Staff (uncredited)

Luigi Petrazzuolo as Gondolier (uncredited)

Aleksandrs Petukhovs as London Passerby (uncredited)

Annie Pisapia as Traveler (uncredited)

Jivan Xander Ramesh as Pedestrian (uncredited)

Mike Ray as Passerby (uncredited)

Sofia Renee as High School Student (uncredited)

Cailan Robinson as Victoria's Crew (uncredited)

Emmanuel Rodriguez as Airport Traveler (uncredited)

Ray Rosario as TSA Agent (uncredited)

Daniel Ryves as Dad Collecting Kids (uncredited)

Maurice Sardison as Party Goer (uncredited)

Karen-J Sear as American Tourist (uncredited)

Ilya Tank Shilov as Venice Tourist (uncredited)

Davina Sitaram as London Tourist (uncredited)

Joakim Skarli as London Tourist (uncredited)

Lucas Antoine Starrets as Tourist (uncredited)

Faith Tarby as Perfumed Lady (uncredited)

Emily Tebbutt as Venice Tourist (uncredited)

Lesdy Vanessa as Tourist (uncredited)

Jessica VanOss as Student (uncredited)

Joe David Walters as Pawn Shop Owner (uncredited)

Jo Wheatley as Armed Security Officer (uncredited)

Rocco Wu as Peter's Art Classmate (uncredited)

Samantha Mishinski as Student (uncredited)

Aristou Meehan as Italian Boy (uncredited)

Robert Downey Jr. as Tony Stark (archive footage) (uncredited)

Jeff Bridges as Obadiah Stane (archive footage) (uncredited)