Spencer Tracy as Henry Drummond

Fredric March as Matthew Harrison Brady

Gene Kelly as E.K. Hornbeck

Dick York as Bertram T. Cates

Donna Anderson as Rachel Brown

Harry Morgan as Judge Mel

Claude Akins as Rev. Jeremiah Brown

Elliott Reid as Prosecutor Tom Davenport

Paul Hartman as Bailiff Mort Meeker

Philip Coolidge as Mayor Jason Carter

Jimmy Boyd as Howard

Noah Beery Jr. as John Stebbins

Norman Fell as WGN Radio Technician

Gordon Polk as George Sillers

Hope Summers as Mrs. Krebs - Righteous Townswoman

Ray Teal as Jessie H. Dunlap

Renee Godfrey as Mrs. Stebbins

Florence Eldridge as Sarah Brady

John Alban as Courtroom Spectator (uncredited)

Leon Alton as Townsman (uncredited)

Don Ames as Courtroom Spectator (uncredited)

Don Anderson as Courtroom Reporter (uncredited)

Eddie Baker as Courtroom Reporter (uncredited)

Frank Baker as Townsman (uncredited)

John Barton as Townsman (uncredited)

Brandon Beach as Townsman (uncredited)

Gail Bonney as Fundamentalist Woman (uncredited)

Chet Brandenburg as Courtroom Spectator (uncredited)

Brad Brown as Courtroom Photographer (uncredited)

Buck Bucko as Townsman (uncredited)

George Calliga as Courtroom Spectator (uncredited)

Dick Cherney as Townsman (uncredited)

Oliver Cross as Courtroom Reporter (uncredited)

Jack Daly as Eskimo Pie Vendor in Courtroom (uncredited)

Jack Deery as Townsman (uncredited)

Lester Dorr as Dr. John (uncredited)

George Dunn as Banker / Critic at Town Meeting (uncredited)

Donald Elson as Bollinger (uncredited)

Adolph Faylauer as Courtroom Reporter (uncredited)

Duke Fishman as Courtroom Spectator (uncredited)

Raoul Freeman as Courtroom Spectator (uncredited)

David Fresco as Threatening Spectator (uncredited)

Kay Garrett as Courtroom Spectator (uncredited)

Richard George as Young Farmer Carrying Burning Effigy (uncredited)

Helen Gereghty as Courtroom Spectator (uncredited)

Joseph Glick as Courtroom Spectator (uncredited)

James Gonzalez as Scientist (uncredited)

Signe Hack as Townswoman (uncredited)

Stuart Hall as Dr. Amos Keller (uncredited)

Joseph Hamilton as Man Yelling at Brady Welcome (uncredited)

Sam Harris as Townsman (uncredited)

Earle Hodgins as Dr. Britton's Tonic Spieler with Chimp (uncredited)

Tex Holden as Townsman (uncredited)

Wendell Holmes as Banker - Critic at City Meeting (uncredited)

Shep Houghton as Townsman (uncredited)

Colin Kenny as Courtroom Spectator (uncredited)

Johnny Kern as Courtroom Spectator (uncredited)

Perk Lazelle as Townsman (uncredited)

King Lockwood as Courtroom Spectator (uncredited)

Hank Mann as Townsman (uncredited)

Sandee Marriott as Courtroom Spectator (uncredited)

Thomas Martin as Reporter in Courtroom (uncredited)

Harp McGuire as Harry Esterbrook (uncredited)

Frank Mills as Courtroom Spectator (uncredited)

Hans Moebus as Townsman (uncredited)

Robert Osterloh as Sam - Deputy Arresting Cates (uncredited)

Stephen Paylow as Courtroom Spectator (uncredited)

Bob Perry as Courtroom Reporter (uncredited)

Joe Ploski as Courtroom Spectator (uncredited)

Harry 'Snub' Pollard as Townsman (uncredited)

Paul Power as Courtroom Spectator (uncredited)

Waclaw Rekwart as Courtroom Reporter (uncredited)

John Rice as Townsman (uncredited)

Addison Richards as Townsman (uncredited)

Leoda Richards as Woman Diner (uncredited)

Robert Robinson as Townsman (uncredited)

Scott Seaton as Courtroom Spectator (uncredited)

Leslie Sketchley as Bailiff (uncredited)

Stephen Soldi as Courtroom Reporter (uncredited)

Rudy Sooter as Courtroom Reporter (uncredited)

Bert Stevens as Courtroom Spectator (uncredited)

Hal Taggart as Juror (uncredited)

Harry Tenbrook as Courtroom Spectator (uncredited)

George Tracy as Courtroom Spectator (uncredited)

Charles Wagenheim as Hotel Clerk (uncredited)

Justice Watson as Hillsboro Salesman (uncredited)

Will Wright as Bible Salesman (uncredited)