Freddie Prinze Jr. as Pi (voice)

Rob Schneider as Nerissa (voice)

Evan Rachel Wood as Cordelia (voice)

Donal Logue as Troy (voice)

Andy Dick as Dylan / Curious Shark (voice)

Fran Drescher as Pearl (voice)

John Rhys-Davies as Thorton (voice)

R. Lee Ermey as Jack (voice)

Dylan Cash as Young Percy (voice)

Bruno Alexander as Pi's Dad (voice)

David Fickas as Max / Squid No. 3 / Big Shark (voice)

Jimmy Bennett as Young Pi (voice)

Megahn Perry as Percy's Mum / Female Parrotfish (voice)

Mel Rodriguez as Manny / Dr. Tang (voice)

Reedy Gibbs as Pi's Mom (voice)

Richard Epcar as Moe (voice)

Trent Ford as Percy (voice)