Daveigh Chase as Lilo (voice)

Chris Sanders as Stitch / Leroy (voice)

Tia Carrere as Nani (voice)

Zoe Caldwell as Grand Councilwoman (voice)

Kevin McDonald as Pleakley (voice)

Kevin Michael Richardson as Gantu (voice)

Rob Paulsen as Reuben (voice)

Jeff Bennett as Hamsterviel (voice)

David Ogden Stiers as Jumba (voice)

Tara Strong as Angel / Belle / Houdini / Pleakley's GACC Assistant (voice)

Debra Rogers as First Officer Ombit (voice)

Ving Rhames as Cobra Bubbles (voice)

Liliana Mumy as Mertle Edmonds (voice)

Frank Welker as Sparky / Sprout / Mr. Stenchy / Kixx / Hoilo / Slugger (voice)

Nancy Cartwright as Shortstuff / Phantasmo (voice)

Bobcat Goldthwait as Nosy (voice)

Doug Stone as Ensign Getco (voice)

Tress MacNeille as Bonnie / Poxy / Gigi / Topper / Felix / Melty / Amnesio / Cannonball / GACC Van Computer (voice)

Jim Cummings as Heckler (voice) (uncredited)

Jillian Henry as Elena (voice)

Lili Ishida as Yuki (voice)

Rocky McMurray as Clyde (voice)

Kali Whitehurst as Teresa (voice)