Sanjay Dutt as Murli Prasad Sharma "Munna Bhai"

Arshad Warsi as Sankeshwar "Circuit"

Boman Irani as Dr. J. C. Asthana

Gracy Singh as Dr. Suman Asthana "Chinki"

Sunil Dutt as Shri Hari Prasad Sharma

Rohini Hattangadi as Parvati Sharma

Jimmy Shergill as Zaheer

Kurush Deboo as Dr. Rustam Pavri

Yatin Karyekar as Anand Banerjee

Mumaith Khan as Reena

Bomie E. Dotiwala as Rustom's father

Pushkar Shrotri as Professor

Nawazuddin Siddiqui as Pickpocketer

Neha Dubey as Suman's Friend

Rohitashv Gour as Coconut Seller in Park

Surendra Rajan as Janitor

Khurshed Lawyer as Nagrajan Swamy

Priya Bapat as 1st Year Medical Student

Vishal Thakkar as Karan

Anuradha Chandan as Karan's mother