Jyothika as Ganga / Chandramukhi

Rajinikanth as Dr. Saravanan / Vettaiyan Raja

Prabhu as Senthilnathan

Nassar as Kandaswamy

Vadivelu as Murugesan

Avinash as Ramachandra Acharya

Nayanthara as Durga

Vineeth Radhakrishnan as Viswanathan / Gunashekaran

Vijayakumar as Durga's Grandfather

Sheela as Akilandeswari

K R Vijaya as Senthilnathan's Mother

Suvarna Mathew as Swarna

Malavika as Priya

Vinaya Prasad as Lakshmi Kandaswamy

Manobala as Exorcist

Sonu Sood as Oomayan

Thiyagu as Kumar

Mohan Raj as Senthilnathan's work opponent

Madhan Bob as Car Owner

T. P. Gajendran as Senthilnathan's assistant

Sujibala as Kandaswamy's youngest daughter

Unnikrishnan Namboothiri as The temple priest

Ramkumar Ganesan as Self

P. Vasu as Self

Pondy Ravi as Engineer

Sudha as Ganga's Mother

Periya Karuppu Thevar as

Thalapathi Dinesh as