Nick Nolte as Augusto Odone

Susan Sarandon as Michaela Odone

Peter Ustinov as Professor Nikolais

Ann Hearn as Loretta Muscatine

Maduka Steady as Omuori

Aaron Jackson as Francesco Odone

Laura Linney as Young Teacher

Kathleen Wilhoite as Deirdre Murphy

Gerry Bamman as Doctor Judalon

Margo Martindale as Wendy Gimble

James Rebhorn as Ellard Muscatine

Colin Ward as Jake Gimble

LaTanya Richardson Jackson as Nurse Ruth

Jennifer Dundas as Nurse Nancy Jo

William Cameron as Pellerman

Becky Ann Baker as Pellerman's Secretary

Mary Pat Gleason as The Librarian

David Shiner as Clown

Ann Dowd as Pediatrician

Peter MacKenzie as Immunosuppression Doctor

Paul Lazar as Professor Duncan

Joyce Reehling as Columnist

Michael O'Neill as School Psychologist

Richard Cordery as Suddaby's Senior Manager

Angus Barnett as Suddaby's Junior Manager

E. G. Daily as Lorenzo Odone (voice)

Zack O'Malley Greenburg as Lorenzo Odone

Sandy Gore as Murphy Family

Nora Dunfee as Murphy Family

Rocco Sisto as Murphy Family

Amelia Campbell as Murphy Family

Keith Reddin as Murphy Family

Anthony DiLeo Jr. as Conference Parent

Lianne Kressin as Smiling Nurse

Nicolas Petrov as World Bank Executive