Cheech Marin as Cheech

Tommy Chong as Chong

Stacy Keach as The Sarge

Timothy Leary as Self

Evelyn Guerrero as Donna

Paul Reubens as Howie Hamburger Dude

Suzanne Kent as Sidney the Agent

Jeff Pomerantz as CHP #2

James Faracci as CHP #2

Marlena Amey as Beach Girl #2

Levin Bailey as Juvenile Delinquent

Benita Barrie as Mrs. Del Whacko

Sandra Bernhard as Girl Nut

Big Yank as Male Nurse #2

Don Carlson as Nut #7

David Castle as Nut #8

Jerry Chambers as Male Nurse #1

Jennifer Child as Dishwater / Blondie Group #5

Shelby Chong as Body Builder

Tony Cox as Midget Nut

Roderick E. Daniels as Janitor

James William Newport as Grow Room Weirdo

Lorraine Fiorito as Hooker #2

Mickey Fox as Nut #18

Frances Gray as Lady in Elevator

Jeff Imada as Wine Steward

Peter Jason as Det. Drooler

Sally Julian as Chinatown Photographer

Solomon Karriem as Prisoner

Irvin 'Zabo' Koszewski as Body Builder #1

Danny Kwan as Lab Technician

Michael Lansing as Nut #15

Bob Leslie as Nut #6

Robert 'Big Buck' Maffei as Big Guy in the Door Way

Rikki Marin as Blonde in Car

Sally Marr as Nut #5

Michael Masters as Willard "Animal" Bad

David McCharen as Chicken Man

Bill McLean as Nut #12

Gregory Polcyn as Nut #13

Haydee Pomar as Brunetta / Blondie Group #4

Linnea Quigley as Blondie Group #2

Peter Risch as Midget in Cell

Spray Rosso as Hooker #1

Tim Rossovich as Det. Noodles

Roselyn Royce as Beach Girl #3

Malcolm C. Scott as Nut House Resident

Sab Shimono as Oriental Bus Boy

Cheryl Smith as Blondie Group #1

Howlett Smith as Ray

Roosevelt Smith as Policeman

Shirley Spangler as Lady in Elevator

Debbie Tressler as Auburnetta /Blondie Group #3

Victoria Wells as Beach Girl #1

Michael Winslow as Superman Nut

Charlie Young as Brunette in Car