Don Knotts as Dr. Jesse W. Heywood

Barbara Rhoades as Penelope 'Bad Penny' Cushings

Jackie Coogan as Matthew Basch

Ruth McDevitt as Mrs. Olive Heywood

Frank McGrath as Mr. Remington

Terry Wilson as Welsh

Carl Ballantine as Abel Swanson

Pat Morita as Wong

Robert Yuro as Arnold the Kid

Herb Voland as Dr. Friedlander

Fay DeWitt as Violet

Dub Taylor as Pop Cushings

Hope Summers as Celia

Dick Wilson as Black Eagle (Indian chief)

Don 'Red' Barry as Rev. Zachary Gant

Vaughn Taylor as Rev. Longbaugh

Ed Peck as Sheriff

Edward Faulkner as Marshal Sam Huggins

Arthur Space as Sheriff Tolliver

Greg Mullavey as Phelps - Dental Student

Fred Aldrich as Passerby (uncredited)

E.J. André as Will Banks

John Aniston as Indian (uncredited)

Argentina Brunetti as Squaw (uncredited)

Claudia Bryar as Mrs. Remington

Paul Bryar as Man at Bar (uncredited)

Noble 'Kid' Chissell as Townsman (uncredited)

William Christopher as Hotel Manager (uncredited)

Frank Coghlan Jr. as Man at Bar (uncredited)

Warde Donovan as Townsman (uncredited)

Mickey Finn as Father (uncredited)

Myron Healey as Stage Passenger (uncredited)

Charles Horvath as Indian Warrior (uncredited)

Clyde Howdy as Man (uncredited)

I. Stanford Jolley as Bearded Stage Passenger (uncredited)

Gil Lamb as Slosh White - Drunk

James McHale as Conductor (uncredited)

Tina Menard as Squaw (uncredited)

Kathryn Minner as 96-Year-Old Woman (uncredited)

Dorothy Neumann as Mrs. Eva Longbaugh

Eddie Quillan as Train Porter (uncredited)

Bill Quinn as U.S. Marshal Arthur Bates

Rodd Redwing as White Buffalo (uncredited)

Benny Rubin as Man at Bar (uncredited)

Naomi Stevens as Squaw (uncredited)

Boyd Stockman as Stage Driver (uncredited)

Leonard Stone as Bartender (uncredited)

Lorna Thayer as Saloon Girl (uncredited)

Peggy Mondo as Indian Woman in Stagecoach

Jim Boles as Big Spring Townsman (uncredited)

King Moody as Ernie