Hrithik Roshan as Krishna Mehra / Krrish / Rohit Mehra

Priyanka Chopra Jonas as Priya Mehra

Vivek Oberoi as Kaal

Kangana Ranaut as Kaya

Arif Zakaria as Dr. Varun Shetty

Asif Basra as Dr. Alok Sen

Rajpal Yadav as Kripal Sharma

Rakhee Tandon as Sharma's Wife

Sameer Ali Khan as Ant Man

Gowhar Khan as Striker

Nazia Shaikh as Cheetah Woman

Shaurya Chauhan as Scorpion Woman

Amitabh Bachchan as Narrator

Sachin Khedekar as Minister (Special Appearance)

Naseeruddin Shah as Dr. Siddhant Arya (Special Appearance)

Mohnish Behl as Kaal's Adoptive Father (Special Appearance)

Raju Kher as Dr. Alok Sen

Daniel Kaleb as Rhino Man