Hrithik Roshan as Krishna Mehra / Krrish / Rohit Mehra

Priyanka Chopra Jonas as Priya

Rekha as Sonia Mehra

Naseeruddin Shah as Dr. Siddhant Arya

Sharat Saxena as Vikram Sinha

Manini Mishra as Honey

Archana Puran Singh as Nayanatara

Hemant Pandey as Bahadur

Puneet Issar as Komal Singh

Xia Bin as Kristian Li

Yu Xuan as Kristian Li's Sister

Akash Khurana as Catholic School Principal

Micky Dhamijani as Teen Krishna Mehra

Kiran Juneja as Priya's Mother (Cameo)

Preity Zinta as Nisha Mehra (Cameo)