Alan Rickman as Dr. Alfred Blalock

Yasiin Bey as Vivien Thomas

Kyra Sedgwick as Mary Blalock

Gabrielle Union as Clara Thomas

Merritt Wever as Mrs. Saxon

Charles S. Dutton as William Thomas

Mary Stuart Masterson as Dr. Helen Taussig

Irene Ziegler as Francis Grebel

Luray Cooper as Charles Manlove

Cliff McMullen as Lodel Williams

Clayton LeBouef as Harold Thomas

James Lewis as Medical Intern