Cary Grant as Mortimer Brewster

Priscilla Lane as Elaine Harper Brewster

Josephine Hull as Aunt Abby Brewster

Jean Adair as Aunt Martha Brewster

Raymond Massey as Jonathan Brewster

John Alexander as 'Teddy Roosevelt' Brewster

Peter Lorre as Dr. Einstein

Jack Carson as Officer Patrick O'Hara

Edward Everett Horton as Mr. Witherspoon

James Gleason as Lt. Rooney

Grant Mitchell as Reverend Harper

Edward McNamara as Sergeant Brophy

Garry Owen as Taxi Cab Driver

John Ridgely as Officer Saunders

Vaughan Glaser as Judge Cullman

Chester Clute as Dr. Gilchrist

Charles Lane as Reporter at Marriage License Office

Edward McWade as Gibbs

Hank Mann as Photographer at Marriage License Office (uncredited)

Spencer Charters as Marriage License Clerk

Sol Gorss as New York Pitcher (uncredited)

Lee Phelps as Umpire (uncredited)

Raymond Walburn as Drummer at baseball game (uncredited)

Spec O'Donnell as Young Man in Line (uncredited)

Leo White as Man in Phone Booth (uncredited)