Vera Farmiga as Kate

Peter Sarsgaard as John

Isabelle Fuhrman as Esther

CCH Pounder as Sister Abigail

Jimmy Bennett as Daniel

Margo Martindale as Dr. Browning

Karel Roden as Dr. Värava

Aryana Engineer as Max

Rosemary Dunsmore as Grandma Barbara

Jamie Young as Brenda

Lorry Ayers as Joyce

Brendan Wall as Detective

Genelle Williams as Sister Judith

Mustafa Abdelkarim as Daniel's Friend

Landon Norris as Daniel's Friend

Julien Elia as Hospital Receptionist

Leni Parker as Delivery Room Nurse

Gemma James Smith as Teacher

Pia Ajango as Saarne Institute Receptionist

Matthew Raudsepp as Saarne Institute Orderly

Sugith Varughese as ICU Doctor

Luis Oliva as ICU Nurse

Ferelith Young as Waiting Room Nurse

Andrew Shaver as Injection Doctor