Susan Sarandon as Adele August

Natalie Portman as Ann August

Hart Bochner as Josh Spritzer

Eileen Ryan as Lillian

Ray Baker as Ted

John Diehl as Jimmy

Shawn Hatosy as Benny

Bonnie Bedelia as Carol

Faran Tahir as Hisham Badir

Shishir Kurup as Hisham Badir (voice)

Elisabeth Moss as Rachel

John Carroll Lynch as Jack Irwin

Caroline Aaron as Gail Letterfine

Paul Guilfoyle as George Franklin

Thora Birch as Mary

Mary Ellen Trainor as Homeowner

Ashley Johnson as Sarah

Corbin Allred as Peter

Eva Amurri as Girl on TV

Heather DeLoach as Ellen

Stephanie Niznik as Waitress

Heather McComb as Janice Pearlman

Lindley Harrison as Janice's Mother

Michael Milhoan as Cop

Robert Duvall as Bernie

Nina Leichtling as Josh's Wife

Jay Harrington as Waiter

Andy Bowles as Mourner

Rick Hurst as Reverend

Rachel Wilson as Sylvia

Stephen Berra as Hal

Nina Barry as Casting Assistant

Cricky Long as Casting Executive

Lillian Adams as Jack's Mother

Megan Mullally as Woman Buying Car

George Peck as Man with Luggage