Harrison Ford as Indiana Jones

Cate Blanchett as Irina Spalko

Karen Allen as Marion Ravenwood

Shia LaBeouf as Mutt Williams

Ray Winstone as George 'Mac' McHale

John Hurt as Professor Harold Oxley

Jim Broadbent as Dean Charles Stanforth

Igor Jijikine as Antonin Dovchenko

Dimitri Diatchenko as Russian Suit

Ilia Volok as Russian Suit

Emmanuel Todorov as Russian Soldier

Pasha D. Lychnikoff as Russian Soldier

Andrew Divoff as Russian Soldier

Venya Manzyuk as Russian Soldier

Alan Dale as General Bob Ross

Joel Stoffer as Taylor

Neil Flynn as Smith

Vincent Foster as Minister

Chet Hanks as Student in Library

Brian Knutson as Letterman

Dean Grimes as Letterman

Sasha Spielberg as Slugger

Nicole Luther as Diner Waitress

Sophia Stewart as Malt Shop Teen

Chris Todd as College Brawler

Dennis Nusbaum as College Brawler

T. Ryan Mooney as Teenage Boy

Audi Resendez as Teenage Girl

Helena Barrett as Teenage Girl

Carlos Linares as Fast Speaking Inmate

Gustavo Hernandez as Shouting Inmate

Maria Luisa Minelli as Sanitarium Nun

Nito Larioza as Cemetery Warrior

Ernie Reyes Jr. as Cemetery Warrior

Jon Valera as Cave Warrior

Kevin Collins as M.P. in Guard Hut

Robert Baker as M.P. Sergeant

Andre Alexsen as Russian Soldier #1 (uncredited)

Greg Anthony as Ugha Warrior (uncredited)

Ryan Bair as Varsity Football Player (uncredited)

Jon Braver as Staff Car Driver (uncredited)

Kyle Brody as Peruvian Village Boy (uncredited)

Amanda Bromberg as Wedding Guest (uncredited)

Noelle Bruno as Greaser Girl (uncredited)

Chris Bryant as Student (uncredited)

Kevin Patrick Burke as Russian Soldier (uncredited)

Tim Camarillo as Peruvian Villager (uncredited)

Arnold Chon as Ugha Mud Warrior (uncredited)

Jared Christopherson as College Student (uncredited)

Al Conti as Professor (uncredited)

Marly Coronel as Villager (uncredited)

Martin Dew as Russian Scientist (uncredited)

Holland Diaz as Ugha Mud Warrior (uncredited)

John Dixon as Russian Driver (uncredited)

Ken Edling as Traveler (uncredited)

Denholm Elliott as Marcus Brody (archive footage) (uncredited)

Larry Eudene as Dr. Pavlov - Russian Scientist (uncredited)

Colin Follenweider as Joe College (uncredited)

Erin Frederick as Surprised Library Student (uncredited)

Andrew Goldfarb as Protesting Student (uncredited)

Ted Grossman as Peruvian Porter (uncredited)

Celia Hemken as Deirdre Stanforth (uncredited)

Michael J. Jacyna as Russian Military Cameraman (uncredited)

Joe Jagatic as Russian Soldier (uncredited)

Alexander Kaminer as Russian Soldier (uncredited)

Brendon John Kelly as College Student (uncredited)

Adam Kirley as Teenage Boy Car Driver (uncredited)

Katie Knopf as Cheerleader (uncredited)

Gregory Kudanovych as Russian Soldier (uncredited)

David LaVera as Toba - Mayan Warrior (uncredited)

Jonathan Lomma as Train Passenger (uncredited)

Janet López as Candle Seller / Peru Villager (uncredited)

Michael Maddigan as Greaser (uncredited)

Chuck Maldonado as Cemetery Warrior (uncredited)

Sean Marrinan as Hellman's Bakery Delivery Man (uncredited)

Anthony Martins as Ugha Warrior (uncredited)

Derek Mears as Russian Soldier (uncredited)

Juan Manuel Mendiola Jr. as Airman (uncredited)

Steven A. Miller as College Student (uncredited)

Josh Mills as Tim Holt (uncredited)

Johanna Monasterios as Student (uncredited)

Lee Morrison as Russian Driver (uncredited)

Ian Novotny as Russian Soldier (uncredited)

Adam Prakop as Student in Library (uncredited)

Ana Maria Quintana as Peruvian Nun (uncredited)

Sam Rocco as College Student (uncredited)

Ilya Rockwell as Russian Soldier (uncredited)

Jason Roehm as Russian Soldier (uncredited)

Errol Sack as Hostile Soldier (uncredited)

Philip J. Silvera as Ugh Mud Warrior (uncredited)

David St. Pierre as Greaser (uncredited)

Bogdan Szumilas as Russian Scientist (uncredited)

Bryan Thompson as Letterman (uncredited)

John H. Tobin as Sierra Madre Cowboy (uncredited)

John Willoughby as Pedestrian (uncredited)

Dianne Zaremba as College Student (uncredited)

Ilya Jonathan Zaydenberg as Russian Soldier #5 (uncredited)