Christina Ricci as Yellow (voice)

Sean Astin as Horatio (voice)

Jessica Capshaw as Duck (voice)

Craig Ferguson as Nat (voice)

E. G. Daily as (voices)

Rosie Perez as Red (voice)

Tara Strong as (voice)

Wayne Brady as Blue (voice)

Owen Wilson as Ricky The Dragon (voice)

Jess Harnell as Green (voice)

David Kaye as Black (voice)

Jeremy Guskin as Professor Heliotrope (voice)

Frank Gladstone as Astronaut (voice)

Zoë Bright as Madame Pink (voice)

Sophia Eraklis as Purple (voice)