Teresa Wright as Young Charlie

Joseph Cotten as Uncle Charlie

Macdonald Carey as Jack Graham

Henry Travers as Joseph Newton

Patricia Collinge as Emma Newton

Hume Cronyn as Herbie Hawkins

Wallace Ford as Fred Saunders

Edna May Wonacott as Ann Newton

Charles Bates as Roger Newton

Irving Bacon as Station Master

Clarence Muse as Pullman Porter

Janet Shaw as Louise Finch

Estelle Jewell as Catherine

Virginia Brissac as Mrs. Phillips (uncredited)

Frances Carson as Mrs. Potter (uncredited)

Earle S. Dewey as Mr. Norton (uncredited)

Sarah Edwards as Doctor's Wife on Train (uncredited)

Edward Fielding as Doctor on Train (uncredited)

Vaughan Glaser as Dr. Phillips (uncredited)

Alfred Hitchcock as Man on Train Playing Cards (uncredited)

Shep Houghton as Ballroom Dancer (uncredited)

Ruth Lee as Mrs. MacCurdy (uncredited)

Eily Malyon as Mrs. Cochran (uncredited)

John McGuire as Teen at Crosswalk (uncredited)

Shirley Mills as Shirley (uncredited)

Constance Purdy as Mrs. Martin (uncredited)

Robert Quarry as Santa Rosa Teenager (uncredited)

Isabel Randolph as Margaret Green (uncredited)

Grandon Rhodes as Rev. MacCurdy (uncredited)

Byron Shores as Detective (uncredited)

Edwin Stanley as Mr. Green (uncredited)

Minerva Urecal as Mrs. Henderson (uncredited)