Sean Patrick Flanery as Indiana Jones

Lloyd Owen as Professor Henry Jones, Sr.

Ronny Coutteure as Remy Baudouin

Robyn Lively as Nancy Stratemeyer

Francesco Quinn as Francois

Mike Moroff as Pancho Villa

Mark L. Taylor as Professor Thompson

Clark Gregg as Dickinson

James Handy as Frank Brady

Antonio Valero as Julio Cárdenas

Peter Marinker as Pershing

Stuart Milligan as Lt. George Patton

Steve Graf as Frank

Ed Bishop as Sentry

John Asher as Clifford

Tim Halligan as Uncle Fred

Deborah Strang as Aunt Grace

Carlos Douglas as Mexican Banker

Zia Harris as Old Man in Pueblo

Chuck Wentworth as Pilot

Lonnie Horsey as Butch

Dorothee Brandenburg as Rosie

Lee Lively as Edward Stratemeyer

Jeromie Wilson as Mrs. Stratemeyer

Thea Mills as Jewel Williams

Rick Warner as Howard Butler

Marilyn Allen as Thompson's Wife

Richard K. Olsen as Thomas Edison

Michael Titterton as Teacher

Eric Lavoie as Ricky

Pearl Jones as Mrs. Brennan

Robert V. Girolami as Security Guard

Dick Latessa as Willie

Jeffrey Long as Race Car Driver

Ken Sprunt as Kurt

Robert Pentz as Herman

Vic Tablian as Demetrios / Claw