Frank Zappa as Self (archive footage)

Mike Keneally as Self - Played with Zappa 1987-1988

Pamela Des Barres as Self - Author, Former Member of the GTOs

Lonnie Lardner as Self - Newscaster for Action News (archive footage)

Patrice Zappa as Self - Frank Zappa's Sister (archive footage)

Rose Zappa as Self - Frank Zappa's Mother (archive footage)

Francis Zappa as Self - Frank Zappa's Father (archive footage)

Edgard Varèse as Self (archive footage)

Don Van Vliet as Self (archive footage) (as Captain Beefheart)

The Mothers of Invention as Themselves (archive footage)

Johnny Guitar Watson as Self (archive footage)

Pamela Zarubica as Self - Zappa's Roommate

Carlo Zappavigna as Self - Frank Zappa's Brother (archive footage)

Bunk Gardner as Self - Played with Zappa 1966-1969

Ian Underwood as Self - Played with Zappa 1967-1975

Ruth Underwood as Self - Played with Zappa 1967-1976

Gail Zappa as Self - Frank Zappa's Wife

Tom Wilson as Self - Music Producer (archive footage)

Euclid James 'Motorhead' Sherwood as Self - Baritone Saxophone / Percusion (archive footage)

Roy Estrada as Self - Bass (archive footage)

Ray Collins as Self - Vocal (archive footage)

Don Preston as Self - Keyboards (archive footage)

Jimmy Carl Black as Self - Drums (archive footage)

Arthur Dyer Tripp III as Self - Percusion (archive footage) (as Art Tripp)

Cal Schenkel as Self (archive footage)

Jimi Hendrix as Self (archive footage)

Moon Unit Zappa as Self (archive footage)

Ronald Reagan as Self (archive footage)

Nancy Reagan as Self (archive footage)

David Bowie as Self (archive footage)

Mick Jagger as Self (archive footage)

Joni Mitchell as Self (archive footage)

Dweezil Zappa as Self (archive footage)

Alice Cooper as Self (archive footage)

Howard Kaylan as Self (archive footage)

Mark Volman as Self (archive footage)

Aynsley Dunbar as Self - Drums (archive footage)

Jeff Simmons as Self - Bass (archive footage)

George Duke as Self - Keyboards / Trombone (archive footage)

Jean-Luc Ponty as Self (archive footage)

Yoko Ono as Self (archive footage)

John Lennon as Self (archive footage)

Jerry D. Good as Self - Producer, 200 Motels (archive footage) (as Jerry Good)

Ringo Starr as Self (archive footage)

Steve Vai as Self - Played with Zappa 1980-1982

Ike Willis as Self - Played with Zappa 1978-1979 (archive footage)

Bruce Bickford as Self - Animator

Tom Fowler as Self (archive footage)

Napoleon Murphy Brock as Self (archive footage) (as Napoleon Brock)

Ralph Humphrey as Self (archive footage)

Chester Thompson as Self (archive footage)

Bruce Fowler as Self (archive footage)

Patrick O'Hearn as Self (archive footage)

Peter Wolf as Self (archive footage)

Terry Bozzio as Self (archive footage)

Tommy Mars as Self (archive footage)

Adrian Belew as Self (archive footage)

Scott Thunes as Self - Played with Zappa 1981-1988

Joe Travers as Self

John Belushi as Self (archive footage)

Ray White as Self - Played with Zappa 1976-1984

Arthur Barrow as Self (archive footage)

Vinnie Colaiuta as Self (archive footage)

Diva Zappa as Self (archive footage)

Sandi Freeman as Self (archive footage)

Mike Douglas as Self (archive footage)

Norman Seeff as Self (archive footage)

David Harrington as Self

Robin Denselow as Self (archive footage)

Kent Nagano as Self (archive footage)

David Letterman as Self (archive footage)

Ahmet Zappa as Self (archive footage)

Pierre Boulez as Self (archive footage)

David Raksin as Self (archive footage)

Ted Koppel as Self (archive footage)

Susan Baker as Self - PMRC Member (archive footage)

Arsenio Hall as Self (archive footage)

Gary Iskowitz as Self (voice)

David Dondorf as Self - Music Engineer (voice)

Kathleen Sullivan as Self (archive footage)

Václav Havel as Self - President of Czechoslovakia (archive footage)

Jamie Gangel as Self (archive footage)

Ensemble Modern as Themselves (archive footage)

Arthur Brown as Self (archive footage)

Adam Curry as Self

Hank Dutt as Self

Buzz Gardner as Self (archive footage)

Al Gore as Self (archive footage)

Tipper Gore as Self (archive footage)

David Harrington as Self (archive footage)

Brian Jones as Self (archive footage)

John Lofton as Self (archive footage)

Miss Mercy as Self (archive footage)

John Sherba as Self

Bill Wyman as Self (archive footage)

Sunny Yang as Self

Charles Manson as Self (archive footage)