James McAvoy as Victor Frankenstein

Daniel Radcliffe as Igor

Jessica Brown Findlay as Lorelei

Andrew Scott as Inspector Turpin

Freddie Fox as Finnegan

Charles Dance as Frankenstein

Daniel Mays as Barnaby

Callum Turner as Alistair

Bronson Webb as Rafferty

Spencer Wilding as Nathaniel / Prometheus 2

Robin Pearce as Baron Bomine

Di Botcher as Older Nun

Eve Ponsonby as Orderly

Will Keen as Surgeon

Louise Brealey as Sexy Society Girl

Nicola Sloane as Housekeeper

Alistair Petrie as Chief Inspector

Neil Bell as Huntsman

Mark Gatiss as Dettweiler

Guillaume Delaunay as Prometheus 1

Robert J. Fraser as Livery Man (uncredited)

Valene Kane as Mrs. Winthrop (uncredited)

Adrian Schiller as Dr. Clive (uncredited)