Diego Luna as Manolo (voice)

Channing Tatum as Joaquin (voice)

Zoe Saldaña as Maria (voice)

Christina Applegate as Mary Beth (voice)

Eugenio Derbez as Chato (voice)

Cheech Marin as Pancho Rodriguez (voice)

Gabriel Iglesias as Pepe Rodriguez (voice)

Ron Perlman as Xibalba (voice)

Kate del Castillo as La Muerte (voice)

Ana de la Reguera as Carmen Sánchez (voice)

Dan Navarro as Chakal (voice)

Ice Cube as Candle Maker (voice)

Héctor Elizondo as Carlos Sanchez (voice)

Danny Trejo as Skeleton Luis (voice)

Carlos Alazraqui as General Posada / Dali / Chuy (voice)

Emil-Bastien Bouffard as Young Manolo (voice)

Elijah Rodriguez as Young Joaquin

Genesis Ochoa as Young Maria (voice)

Plácido Domingo as Skeleton Jorge (voice)

Grey DeLisle as Grandmother (voice) (as Grey Griffin)

Trey Bumpass as Goth Kid / Orphan

Miguel Sandoval as Land of the Remembered Captain (voice)

Ben Gleib as Goya / Dali (voice)

Ricardo El Mandril Sanchez as Pablo Rodriguez (voice)

Ishan Sharma as Sanjay

Jorge R. Gutierrez as Skeleton Carmelo (voice)

Anjelah Johnson-Reyes as Adelita / Nina (voice)

Kennedy Peil as Sasha (voice)

Sandra Equihua as Scardelita (voice)

Callahan Clark as Jane (voice)

Gunnar Sizemore as Ignacio (voice)

Angélica María as Sister Ana (voice)

Eric Bauza as Father Domingo / Cave Guardian (voice)

Aron Warner as Thomas (voice)

Sandra Echeverría as Claudia (voice)

Tonita Castro as La Muerte as Old Woman (voice)

Troy Evans as Old Man Hemingway (voice)

Guillermo del Toro as Land of the Remembered Captain's Wife (voice)

Brad Booker as Conductor (voice)

Rosemary Alexander as Additional Voices (voice)

Steve Alterman as Additional Voices (voice)

Eva Bella as Additional Voices (voice)

Madison Carlon as Additional Voices (voice)

Vicki Davis as Additional Voices (voice)

Moosie Drier as Additional Voices (voice)

Cullen McCarthy as Additional Voices (voice)

David Michie as Additional Voices (voice)

Michelle Moores as Additional Voices (voice)

Jonathan Nichols-Navarro as Additional Voices (voice)

Al Rodrigo as Additional Voices (voice)

Marcelo Tubert as Additional Voices (voice)

Lynnanne Zager as Additional Voices (voice)

Ruth Zalduondo as Additional Voices (voice)

Newell Alexander as Additional Voices (voice)

David Cowgill as Additional Voices (voice)

Elisa Gabrielli as Additional Voices (voice)

Richard Miro as Additional Voices (voice)

Arthur Ortiz as Additional Voices (voice)

Nathaniel Semsen as Additional Voices (voice)

Joe Matthews as Young Manolo (singer)

Jose Alvarez as Additional Voices (voice) (uncredited)