Dustin Hoffman as Mr. Edward Magorium

Natalie Portman as Molly Mahoney

Jason Bateman as Henry Weston

Zach Mills as Eric Applebaum

Jonathan Potts as Dr. Sage

Rebecca Northan as Ellie Applebaum

David Rendall as Tim

Jade Cohen as Kangaroo Girl

Marcia Bennett as Lora

Ted Ludzik as Bellini

Madalena Brancatella as Jessica

Paula Boudreau as Brenda

Mike Realba as Dave Wolf

Steve Whitmire as Kermit the Frog (voice)

Liam Powley-Webster as Andy

Oliver Masuda as Jordan

Samantha Harvey as Cassie

Jesse Bostick as Derek

Isaac Durnford as Jason

Daniyah Ysrayl as Jimmy

Dash Grundy as Ari

Dylan Authors as Mark

Aidan Koper as Brett

Lin Lin Feng as Angie

He Wen as Larry

Gan Zhen as David

Quancetia Hamilton as Gia

Kiele Sanchez as Mrs. Goodman

David Collins as Tom

Matt Baram as Eddie, the Dentist

Mathew Peart as Wyatt, Who Sells Hot Dogs

Michael Costa Parke as Jack, Who Thinks It's Magic (as Michael Costa-Parke)

Milo Gladstein as Milo, Who's Not Bad

Kerry-Lee Finkle as Funeral Attendee (uncredited)

Austin Macdonald as Boy in toy store (uncredited)

Mani Nasry as Mani (uncredited)

Christina Orjalo as Shop Girl (uncredited)

Jordan Dean Scott as Boy on Scooter (uncredited)

Daniella Tokic as Nurse (uncredited)

Beatriz Yuste as Lora (uncredited)