Meryl Streep as Jane Adler

Alec Baldwin as Jake Adler

Steve Martin as Adam Schaffer

John Krasinski as Harley

Caitlin FitzGerald as Lauren Adler

Hunter Parrish as Luke Adler

Zoe Kazan as Gabby Adler

Lake Bell as Agness Adler

Mary Kay Place as Joanne

Rita Wilson as Trisha

Ali Wentworth as Diane

Emjay Anthony as Pedro Adler

Nora Dunn as Sally

Bruce Altman as Ted

Robert Curtis Brown as Peter

James Patrick Stuart as Dr. Moss

Peter MacKenzie as Dr. Allen

Pat Finn as Hotel Doctor

Heitor Pereira as Party Musician

Ramin Djawadi as Party Musician

Ryeland Allison as Party Musician

Sean Hamrin as Oliver

Valente Rodriguez as Reynaldo

Emily Kinney as Waitress

Amelia Rasche McCarthy as Bakery Manager

Zack Robidas as Hotel Reception Clerk

Lisa Masters as Woman in Elevator

Scott Geyer as Man in Elevator

Andrew Stewart-Jones as Restaurant Host

Jon Frazier as Bartender

Ryan Silverman as Bartender

Jennifer Restivo as Woman at Bar

Dana Power as Woman at Bar

Michael Kopp as Self-Help Narrator (voice)

Michael Rivera as Eddie

Jennifer Eatz as Woman at Fertility Clinic

Blanchard Ryan as Woman at Fertility Clinic

Geneva Carr as Woman at Fertility Clinic

Eric Rath as Man at Fertility Clinic

Philip Coccioletti as Man at Fertility Clinic

Deidre Goodwin as Fertility Nurse

Rosalie Ward as Biltmore Reception Clerk

Jessica St. Clair as Wedding Specialist

Marina Squerciati as Melanie

Ricardo Chacon as Police Officer

Michael Yavnielli as Police Officer

Robert Adamson as College Kid at Party

Patrick King Jr. as College Kid at Party

Donessa Alexander as Pedestrian (uncredited)

Wesley Alfvin as Hotel Guest (uncredited)

Ava Allan as Christmas Tree Shopper (uncredited)

Deborah Bowman as Bakery Assistant (uncredited)

Giovanni Cirfiera as Businessman (uncredited)

Jimmy Clabots as College Kid at Party (uncredited)

Debra Lord Cooke as Principal Dancer (uncredited)

Michelle Liu Coughlin as Woman at Fertility Clinic (uncredited)

Molly Culver as Adam's Girlfriend in Dream (uncredited)

Alan Cumming as TV Actor (uncredited)

Cynthia Daddona as Upscale Farmer's Market Shopper (uncredited)

Michael Dean as Upscale Café Patron (uncredited)

Rick Dean as Party Guest (uncredited)

Shakira Vanise Gamble as Woman at Fertility Clinic (uncredited)

Daniel Gold as Graduating Student (uncredited)

Anthony Gusevich as College Graduate (uncredited)

Meryl Hathaway as Bakery Server (uncredited)

Rebecca Hyland as Miss Bascom (uncredited)

Jeremiah Krage as Elevator Man (uncredited)

Anna Kuchma as Bakery Server (uncredited)

Janice LaFlam as Graduation Guest (uncredited)

Anne Lockhart as Party Guest (uncredited)

John Mitchell as Graduation Guest (uncredited)

Lauren L. Murray as Bakery Woman (uncredited)

Matthew Nadu as College Graduate (uncredited)

Jason Andrew O'Malley as Waiter (uncredited)

Louis C. Oberlander as Bohemian Gallery Owner (uncredited)

Regina Palian as Party Guest (uncredited)

Dorota Puzio as Party Guest (uncredited)

Stephanie Maura Sanchez as Biltmore Lobby Guest (uncredited)

Derek Schreck as College Student (uncredited)

Pooja Singh as College Student (uncredited)

Pleasant Wayne as Resort Wife (uncredited)

Steven Weisz as Graduation Guest (uncredited)

Oprah Winfrey as Self (uncredited)

Meghan Wolf as Waitress (uncredited)