Nia Vardalos as Georgia Ianakopolis

Richard Dreyfuss as Irv Gideon

Alexis Georgoulis as Poupi Kakas

Alistair McGowan as Nico

Harland Williams as Big Al Sawchuck

Rachel Dratch as Kim

Caroline Goodall as Dr. Elizabeth Tullen

Ian Ogilvy as Mr. Stewart Tullen

Sophie Stuckey as Caitlin

María Botto as Lala Cruz

María Adánez as Lena

Brian Palermo as Marc

Jareb Dauplaise as Gator

Simon Gleeson as Ken

Natalie O'Donnell as Sue

Sheila Bernette as Dorcas

Ralph Nossek as Barnaby

Bernice Stegers as Maria

Rita Wilson as Elinor

Ian Gomez as Hotel Clerk

Takis Papamattheou as Souvenir Shop Owner

Serenella as Svetlana

Marta Schweizer as Olga

María Ripalda as Lenka

Nacho Pérez as Doudi Kakas

Nadav Malamud as Greek Man 1

Roland Sanden as Greek Man 2

Vassilis Psychogiopoulos as Souvlaki Guy

José María Sacristán as Jewelry Shop Owner

Alberto Santiago as Bar Owner

Alex Spijksma as Bartender

María José Goyanes as Dour Nurse

Jennifer Rope as Pretty Nurse

Melina Kyriakopoulou as Angry Canadian

Denise Moreno as Kathy

Lorin Dreyfuss as Irv's Photo Double

Macarena Benites as Canadian Tourist (uncredited)

Christina Mitropoulou as Canadian Tourist (uncredited)

Heather Blair as American Tourist (uncredited)

David M. Antón as Man on street