Joe Alaskey as Erik the Newscaster (voice)

Ken Foree as Luke St. Luke (voice)

Sheri Moon Zombie as Suzi X (voice)

Tom Papa as El Superbeasto (voice)

Rosario Dawson as Velvet Von Black (voice)

April Winchell as Dame Grace Appleton / Liza / Babs / Dolly / Joan / Gloria / Scripty / Helga Strudel (voice)

Tom Kenny as Rover / Otto / Old Man / Herbie (voice)

Dee Wallace as Trixie (voice)

Laraine Newman as Lefty / Kate / Courtney / Smelga Strudel / Betty Sue Lou (voice)

Cassandra Peterson as Amber (voice)

Jess Harnell as Uncle Carl (voice)

Harland Williams as Gerard the Exterminator (voice)

Rob Paulsen as Michael / Commercial Voice / Bobby Hyde / Commandant Hess / Assistant Cameraman / El Gato / Grossburger / Creature Preacher (voice)

Debra Wilson as Cigarette Girl / Bride Fronkenstein / Female Patron / Stripper in Hall / Telephone Victim / Old Woman (voice)

Tom Klein as Mr. Fly (voice)

Clint Howard as Joe Cthulu (voice)

Brian Posehn as Murray (voice)

Dee Bradley Baker as Nazi Zombie (voice)

Paul Giamatti as Dr. Satan (voice)

Geoffrey Lewis as Lenny (voice)

John DiMaggio as Burt the Spurt (voice)

Jeff Bennett as Nerdy Patron (voice)

Danny Trejo as Rico (voice)

Carlos Alazraqui as Bennie Redriguez (voice)

Tura Satana as Varla (voice)

Bill Moseley as Otis Driftwood (voice)

Rodger Bumpass as Screaming Patron (voice)

Sid Haig as Captain Spaulding (voice)

Charlie Adler as Krongarr / Mooney McMoon / Albino Singer (voice)

Kevin Michael Richardson as Santa Baby (voice)

Daniel Roebuck as Morris Green (voice)

Christopher Corey Smith as Walla Voodoo (voice)

Zach Hanks as Walla Voodoo (voice)

Ezra Weisz as Walla Voodoo (voice)

Karen Strassman as Walla Voodoo (voice)