Rob Lowe as John F. Kennedy

Will Rothhaar as Lee Harvey Oswald

Ginnifer Goodwin as Jacqueline Kennedy

Michelle Trachtenberg as Marina Oswald

Jack Noseworthy as Robert F. Kennedy

Casey Siemaszko as Jack Ruby

Jamie McShane as Richard Snyder

Mary Pat Gleason as Marguerite Oswald

Boris McGiver as John Fain

Antoinette LaVecchia as Lady Bird Johnson

Francis Guinan as Lyndon B. Johnson

Richard Flood as Kenny O'Donnell

Jody Matzer as Lead Trauma Surgeon

Boris McGiver as FBI Agent

Brian Hutchison as Winston Lawson

Peter Rini as Agent Mooney

Roger W. Durrett as Admiral Burke

Danny McCarthy as Agent James Hosty

Parker Dowling as Buell Wesley Frazier

Mike Shiflett as Captain Will Fritz

Natalie Gold as Ruth Paine

Juan Pablo Veizaga as Carlos Bringuier

Jason B. McIntosh as Charles Givens

Richard Warner as Chester Bowles

William L. Thomas as Clint Hill

Angelo Reyes as First Cuban

Jose Luis Munoz as Second Cuban

Terry Menefee Gau as Nurse Doris Nelson

Bonnie Johnson as Earlene Roberts

Joe Duquette as Eusebio Azcue

John Moon as Father Oscar Huber

Demosthenes Chrysan as George De Mohrenschildt

Solomon Gibson III as George Thomas

Keith Tyree as Governor John Connolly

Ford Flannagan as Howard Brennan

Pete Burris as John Quigley

Ray Nedzel as McGeorge Bundy

Charles Wissinger as Malcolm Kilduff

L. Derek Leonidoff as Marion Baker

Matt Micou as Officer J.D. Tippit

Dan Stearns as Reporter

Gregory Williams as Roy Truly

Robert C. Treveiler as Sheriff's Deputy

Mark Ziv as Sterling Wood

Jonathan Orcutt as William Whaley

Christopher Wiehl as Agent O'Reilly

Mitchell Hebert as Forrest Sorrels

Peter Toney as Officer Harry Hunter

Jefferson Farber as Worker

Bart Debicki as Max

Mike Marunde as Mike

Shaun Irving as Officer

Taylor Roberts as Faddle

Joseph Gray as Sergeant Gerald Hill

Bo Keister as Tony - Bartender

Chris Van Cleave as Doctor George Burkley

Adrienne Nelson as Nell Connally

Kirsten Hauser as Fiddle

Lucas N. Hall as Officer Atwell, Dallas P.D.