Chris Pine as Dave (voice)

Amanda Peet as Ranger (voice)

Samuel L. Jackson as Fear (voice)

Hayden Christensen as Jammer (voice)

Sandra Oh as Gal 2000 (voice)

Robert Picardo as Milton (voice)

James Earl Jones as Admiral (voice)

Mark Hamill as Void (voice)

Tom Kenny as Ignorance (voice)

Jason Alexander as Moronic (voice)

Doug Jones as Zero / Razer (voice)

Brent Spiner as Coach Mackey (voice)

William Shatner as Core (voice)

Casey Kasem as Self (voice)

Abigail Breslin as Jeana (voice)

Spencer Breslin as Anthony (voice)

Neil Armstrong as Dr. Jack Morrow (voice)

Jason Harris as Announcer (voice)

Janina Gavankar as Nikki (voice)

Jeremy Shada as Photon Kid (voice)

Kristen Combs as Photon Kid (voice)

Damani Roberts as Photon Kid (voice)

Kerris Dorsey as Photon Kid (voice)

Gary Graham as Green / Red Photon Fighter (voice)

Dan St. Pierre as Core Deck Officer #1 (voice)

Harry 'Doc' Kloor as Core Deck Officer #2 (voice)

Herbert Jefferson Jr. as Walla (voice)

Kirk Baily as Walla (voice)

Stephen Apostolina as Walla (voice)

Hope Levy as Walla (voice)

John Hans Tester as Walla (voice)

Eddie Frierson as Walla (voice)

Don Fullilove as Walla (voice)

Erin Donovan as Walla (voice)

Edith Mirman as Walla (voice)

Cameron Clarke as Walla (voice)

Rayna Napali as Walla (voice)