Malcolm McDowell as Dr. Samuel Loomis

Scout Taylor-Compton as Laurie Strode

Tyler Mane as Michael Myers

Sheri Moon Zombie as Deborah Myers

Brad Dourif as Sheriff Lee Brackett

Danielle Harris as Annie Brackett

Brea Grant as Mya Rockwell

Howard Hesseman as Uncle Meat

Angela Trimbur as Harley David

Mary Birdsong as Nancy McDonald

Daniel Roebuck as Lou Martini

Bill Fagerbakke as Deputy Webb

Richard Brake as Gary Scott

Dayton Callie as Coroner Hooks

Margot Kidder as Barbara Collier

Richard Riehle as Buddy The Night Watchman

Mark Christopher Lawrence as Deputy Fred King

Jeff Daniel Phillips as Howard / Uncle Seymour Coffins

Chase Wright Vanek as Young Michael

Meagen Fay as Deputy Lyons

Caroline Williams as Dr. Maple

Octavia Spencer as Nurse Daniels

Diane Ayala Goldner as Jane Salvador

Adam Boyer as Bruce Cabot

Duane Whitaker as Sherman Benny

Betsy Rue as Jazlean Benny

Mark Boone Junior as Floyd

Brian Rae as Earl of Pumpkin / Deputy #9

Michael Deak as King Jack / Deputy #10

Mike Kasiske as Lord Treat / Deputy #11

Jake McKinnon as Bishop Trick / Deputy #12

Nicky Whelan as Wendy Snow

Catherine Dyer as Reporter

Sylvia Jefferies as Misty Dawn

Silas Weir Mitchell as Chett Johns

Robert Curtis Brown as Kyle Van Der Klok

Greg Travis as Deputy Neale

Chris Hardwick as David Newman

'Weird Al' Yankovic as Weird Al Yankovic

Matt Lintz as Mark

Graham Marema as Janet

Jesse Dayton as Captain Clegg

Mark Lynch as Teenage Zombie

Matt Bush as Wolfie

Renae Geerlings as Deputy Gwynne

Sean Whalen as Becks

Chris Conner as Sanders

Adam Fristoe as News Producer

Eric Goins as Cameraman

Trevor Pettiford as Sound Guy

Justin Welborn as Mr. Hyde

Michael Scialabba as Paramedic

Eileen Dietz as Winnie Gilmore (uncredited)

Christopher C. Romero as Bartender (uncredited)