Tracy Grandstaff as Daria Morgendorffer (voice)

Wendy Hoopes as Jane Lane / Helen Morgendorffer / Quinn Morgendorffer (voice)

Julián Rebolledo as Jake Morgendorffer (voice)

Alvaro J. Gonzalez as Trent Lane (voice)

Marc Thompson as Anthony DiMartino / Timothy O'Neill / Kevin Thompson / Jamie White (voice)

Russell Hankin as Tom Sloane (voice)

Tim Novikoff as Jeffy (voice)

Steven Huppert as Joey (voice)

Jessica Cydnee Jackson as Jodie Landon (voice)

Amir Williams as Michael Jordan "Mack-Daddy" Mackenzie (voice)

Janie Mertz as Sandi Griffin / Brittany Taylor / Andrea (voice)

Sarah Drew as Stacy Rowe (voice)

Ashley Albert as Tiffany Blum-Decker / Janet Barch (voice)

Geoffrey Arend as Charles "Upchuck" Ruttheimer III (voice)

Nora Laudani as Angela Li (voice)

Bart Fasbender as Andrew Landon (voice)

Laurine Towler as Michele Landon (voice)

Rand Bridges as Bill Woods (voice)

Jessica Hardin as Lindy (voice)