Gregg Turkington as The Comedian

Tye Sheridan as Eddie The Mime

John C. Reilly as John

Lotte Verbeek as The Chromotherapist

Dean Stockwell as Frank

Amy Seimetz as Rene

Tim Heidecker as The Celebrity

Kalia Prescott as Maria

Tonantzin Carmelo as Teresa

Waymond Lee as Prisoner

Ashley Atwood as Pregnant Woman

David Yow as Party Host

Michael Cera as Tommy

Mariann Gavelo as Sitcom Maria

Brenna Rhea as Poolside Girl

Dustin Guy Defa as Ruben

Annabella Lwin as

Sergio Martinez as Fernando