Michael J. Fox as Chance (voice)

Sally Field as Sassy (voice)

Ralph Waite as Shadow (voice)

Robert Hays as Bob Seaver

Kim Greist as Laura Burnford-Seaver

Michael Bell as Stokey (voice)

Tisha Campbell as Sledge (voice)

Al Michaels as Sparky Michaels (voice)

Tommy Lasorda as Lucky Lasorda (voice)

Bob Uecker as Trixie Uecker (voice)

Tress MacNeille as French Poodle (voice)

Jon Polito as Ashcan (voice)

Adam Goldberg as Pete (voice)

Sinbad as Riley (voice)

Carla Gugino as Delilah (voice)

Stephen Tobolowsky as Bando (voice)

Michael Rispoli as Jack

Will Sasso as Pizza Boy

Tom Wagner as Truck Driver

Petey as

Benj Thall as Peter Seaver

Veronica Lauren as Hope Seaver

Kevin Chevalia as Jamie Seaver

Chance the Dog as

Bart the Bear as Bear

Andrew Airlie as Tucker's Dad

Hrothgar Mathews as Animal Control Officer

Max Perlich as Ralph

Ernie Prentice as Poodle Owner

Deryl Hayes as Skycap

Adrienne Carter as Tough Girl