Michael J. Fox as Chance (voice)

Sally Field as Sassy (voice)

Don Ameche as Shadow (voice)

Kevin Chevalia as Jamie Seaver

Benj Thall as Peter Burnford

Veronica Lauren as Hope Burnford

Kim Greist as Laura Burnford-Seaver

Robert Hays as Bob Seaver

Jean Smart as Kate

Gary Taylor as Frank

Anne Christianson as Research Assistant

Ted D'Arms as Vet

Don Alder as Molly's Father

Ed Bernard as Desk Sergeant

William Phipps as Quentin

Frank Welker as Special Vocal Effects (voice)

Bart the Bear as Bear

Woody Eney as Forest Ranger 'Mark'

Rich Hawkins as Forest Ranger

Nurmi Husa as The Caterer

Jane Jones as Molly's Mother

David MacIntyre as Foote

Kit McDonough as Female Forest Ranger

Mary Marsh as Laura's Mom

Glenn Mazen as Minister

Janet Penner as Bob's Mom

Dorothy Roberts as Peter's Teacher

Caroll Spinney as Dog in Pound (uncredited)

Mark L. Taylor as Officer Kirkwood

Ben as Shadow

Rattler as Chance

Tiki as Sassy

Mariah Milner as Molly