Tom Hanks as Joe Banks

Meg Ryan as DeDe / Angelica / Patricia Graynamore

Lloyd Bridges as Samuel Harvey Graynamore

Dan Hedaya as Frank Waturi

Ossie Davis as Marshall

Barry McGovern as Luggage Salesman

Robert Stack as Dr. Ellison

Amanda Plummer as Dagmar

Lala Sloatman as Waitress

Abe Vigoda as Chief of the Waponis

Carol Kane as Hairdresser

Branscombe Richmond as Waponi

Jayne Haynes as Nurse

David Burton as Mike

Jon Conrad Pochron as Tony

Jim Hudson as Fred - Guard

Antoni Gatti as Italian Tailor

Darrell Zwerling as Underwear Salesman

Jim Ryan as Bellman

Karl Rumburg as Ralph

Brian Esteban as Emo - Waponi Lookout

Nathan Lane as Baw - The Waponi Advance Man

Wally Ruiz as Spanish Singer

Guillermo Guzman as Spanish Singer

Tommy Franco as Spanish Singer

Tony Salome as Clerk

Courtney Gibbs as Saleswoman

Jennifer Stewart as Statue of Liberty

William Ward as Salesman - Hammacher Schlemmer

Paul Michael Thorpe as God Woo