Gabourey Sidibe as Precious

Mo'Nique as Mary

Paula Patton as Ms. Rain

Mariah Carey as Ms. Weiss

Sherri Shepherd as Cornrows

Lenny Kravitz as Nurse John

Stephanie Andujar as Rita

Chyna Layne as Rhonda

Amina Robinson as Jermaine

Xosha Roquemore as Joann

Angelic Zambrana as Consuelo

Aunt Dot as Toosie

Nealla Gordon as Mrs. Lichenstein

Grace Hightower as Socialworker

Barret Helms as Tom Cruise

Kimberly Russell as Katherine

Bill Sage as Mr Wicher

Susan Taylor as Fairy Godmother

Kendall Toombs as Abdul, New Born

Alexander Toombs as Abdul, New Born

Cory Davis as Abdul, 9 Months

Rochelle McNaughton as Aids Clerk

Roy Anthony Tarell Harvey as Boy #1

Abigail Savage as Bunny

Rodney "Bear" Jackson as Carl

Sapphire as Day Care Woman

Linda Watson as Female Clerk

Emani Reid as Girl #1

Dashawn Robinson as Girl #2

AzMarie Livingston as Girl with Jermaine

Maurizio Arseni as Italian Language Instructor

Mugga as KFC Cashier

Chazz Menendez as Man #1 Exits Elevator (St)

Roy T. Anderson as Man #2 Exits Elevator (St)

Quisha Powell as Mongo

Vivien Eng as Nurse

Silje Vallevik as Pretty Blonde Girl

Matthew Bralow as Reggie

Shayla Stewart as Ruby

Erica Faye Watson as Sheila

Ephraim Benton as Skinny Boy #1

Shortee Red as Skinny Boy #2

Timothy Allen as Skinny Boy #3

Nigel Joaquin as Unruly Boy #1

Esley Tate as Unruly Boy #2

Alex Manette as Administrator Harris (uncredited)