John Candy as Danny Muldoon

Maureen O'Hara as Rose Muldoon

Ally Sheedy as Theresa Luna

Kevin Dunn as Patrick Muldoon

Milo O’Shea as Doyle

Bert Remsen as Spats

Anthony Quinn as Nick Acropolis

Jim Belushi as Salvatore Buonarte (as James Belushi)

Joe Greco as Johnny Luna

Marvin J. McIntyre as Father Strapovic

Macaulay Culkin as Billy Maldoon

Kieran Culkin as Patrick Muldoon Jr.

Allen Hamilton as O'Neal

Teri McEvoy as Susan Muldoon

Bernie Landis as Larry

Les Podewell as Jack

John Davis Chandler as Duane Earl Tyrone

Martin Fisher as Chess Player

Timothy O'Meara as Cop

James 'Ike' Eichling as Cop

James Deuter as Waiter

John M. Watson Sr. as Leo

Dick Sollenberger as Suit Salesman

Doyle Devereux as Tuxedo Salesman

Clarke Devereux as Tuxedo Salesman / News Vendor

Michael W. Nash as Crazed Prisoner

Porscha Radcliffe as Halloween Bum

Brittany Radcliffe as Halloween Witch

Marlon A. Morris as Cop Friend

Jesse J. Donnelly as Policeman

Sandra Macat as Stewardess

Rick LeFevour as Hoodlum

Mahlon Sharp as Tommy Bones