Robert De Niro as Frank Goode

Drew Barrymore as Rosie

Kate Beckinsale as Amy

Sam Rockwell as Robert

Melissa Leo as Colleen

Damian Young as Jeff

James Frain as Tom

Kate Moennig as Jilly

Brendan Sexton III as Mugger

James Murtaugh as Dr. Ed

Austin Lysy as David

Chandler Frantz as Young David

Lily Mo Sheen as Young Amy

Seamus Davey-Fitzpatrick as Young Robert

Lucian Maisel as Jack

Ben Schwartz as Writer

Mackenzie Milone as Young Rosie

Kene Holliday as Butcher

E.J. Carroll as Wine Man

Lou Carbonneau as BBQ Salesman

Mandell Butler as Delivery Man

Caroline Clay as Amtrak Ticket Agent

Katy Grenfell as Young Woman on First Train

Lynn Cohen as Old Woman on First Train

Jayne Houdyshell as Alice

William J. Slinsky Sr. as Man on Platform

Kelly McAndrew as Hooker

Jason Harris as Cab Rider #1

Julián Rebolledo as Cab Rider #2

Ben Liff as Young Man in Diner #1 (94 Years)

Harvey Liff as Young Man in Diner #2 (86 Years)

Lynn Blades as Anchorwoman

Kevin Collins as Anchorman

Patricia Phillips as NY Woman on Street

Kevin Martin as Man on Bus

Debargo Sanyal as Art Director

Scott Cohen as Music Conductor

Jackie Cronin as Booking Office Lady

Erica Leigh Boseski as Female Orchestra Member

Allie Woods Jr. as Greyhound Station Assistant

Sonja Stuart as Jean Goode

Mimi Lieber as Jean Goode (voice)

Ethan Munsch as Baby Max

Harrison Munsch as Baby Max

Kira Visser as Flight Attendant

Mattie Hawkinson as Art Gallery Girl