Antonio Banderas as Jacq Vaucan

Melanie Griffith as Dr. Susan Dupré / Cleo (voice)

Birgitte Hjort Sørensen as Rachel Vaucan

Dylan McDermott as Wallace

Robert Forster as Robert Bold

Tim McInnerny as Vernon Conway

Andy Nyman as Ellis

David Ryall as Dominic Hawk

Geraldine Somerville as Samantha

Andrew Tiernan as Manager

Christa Campbell as ROC Technician

Christina Tam as Morgue Technician

Danny Kirrane as Muniesa Technician

Philip Rosch as Client

Albena Stavreva as Client's Wife

Javier Bardem as Blue Robot (voice)

Harry Anichkin as Clift

Lyubomir Neikov as Poot

Stanislav Pishtalov as Lance

Bashar Rahal as Doctor

Dan Cade as White Collar Worker