Grey DeLisle as Betsy / Mrs. Yellow Hat (voice)

Frank Welker as George (voice)

Jeff Bennett as The Man with the Yellow Hat / Stew (voice)

Jim Cummings as Chef Pisghetti / Jumpy (voice)

E. G. Daily as Steve / Fireperson Andie (voice)

Debi Derryberry as Gnocchi (voice)

Rob Paulsen as Mr. Reloj / Mr. Dulsen / Charkie (voice)

B.J. Ward as Aunt Margaret (voice)

Rino Romano as Narrator (voice)

Clyde Kusatsu as The Grocer (voice)

Lex Lang as The Doorman / Hundley (voice)

Annie Mumolo as Bill (voice)

James Sie as The Grocer's Son (voice)

Susan Silo as Netti Pisghetti (voice)

Rolonda Watts as Professor Wiseman (voice)